Ammonium adduct ion in ammonia chemical ionization mass spectrometry. Formation of adduct ion.

Study for Catecholamine-2′-Deoxyguanosine Adduct Formation under Biomimetic Conditions Using Liquid Chromatography-Electrospray Ionization-Ion Trap Mass Spectrometry

The adduct formation of 2′-deoxyguanosine (dG) with L-adrenaline under biomimetic conditions (pH 7.5, 37°C) with or without oxidant (MnO2) was demonstrated in order to clarify the reaction mechanism and the structure. At least two adducts have been observed by liquid chromatography-electrospray ionization-ion trap mass spectrometry (LC-ESI-ion trap MS) and LC-photodiode array detection (LC-PAD)...

Development of ion drift-chemical ionization mass spectrometry.

An ion drift-chemical ionization mass spectrometry (ID-CIMS) technique has been developed to detect and quantify trace gases, including volatile organic compounds and inorganic species. The trace species are chemically ionized into positive or negative product ions with a well-controlled ion-molecule reaction time. The ID-CIMS method allows for quantification of the trace gases without the nece...

Plasma polyamines determined by negative-ion chemical ionization/mass spectrometry.

We have developed an accurate and highly sensitive gas-chromatographic/mass-spectrometric procedure for determining di- and polyamines (putrescine, spermidine, and spermine) in plasma and erythrocytes. Deuterium-labeled analogs of putrescine, spermidine, and spermine were synthesized for use as internal standards. Trifluoroacetyl derivatives of the polyamines were formed during the procedure an...

Development of atmospheric pressure ionization ion mobility spectrometry and ion mobility spectrometry mass spectrometry

Electrospray ionization high-resolution ion mobility spectrometry-mass spectrometry.

A hybrid atmospheric pressure ion mobility spectrometer is described which exhibits resolving power approaching the diffusion limit for singly and multiply charged ions (over 200 for the most favorable case). Using an electrospray ionization source and a downstream quadrupole mass spectrometer with electron multiplier as detector, this ESI-IMS-MS instrument demonstrates the potential of IMS for...